W81XWH-10-C-0251 (Streeter PI), 3/1/2012-3/30/2014
Department of Defense: ATO-06: ALERT – A Prospective Evaluation of Biomarkers of Mild, and Moderate Traumatic Brain Injury
Role: Site PI for Washington University
The study evaluates the sensitivity and specificity of two neuronal biomarkers for brain injury: Glial fibrillary acidic protein (GFAP), and ubiquitin C-terminal hydrolase (UCH-L1). The criterion standard consists of both computed tomographic imaging, and neuropsychological (cognitive) testing. The aim is to be able to perform point-of-care testing using these biomarkers on a portable platform and to have rapidly producible results to allow better triaging of imaging, and to better diagnose TBI.
1U01HL088476-01A1 (Vendantham PI), 6/9/2008-3/31/2015
National Institutes of Health/National Heart Lung and Blood Institute Acute Venous Thrombosis Removal with Adjunctive Catheter-directed Thrombolysis: The ATTRACT Trial
Role: (Co-I) Serve as Chair of Enrollment Committee for all sites. This study is a randomized controlled trial comparing the incidence of post-thrombotic syndrome in patients with proximal DVT who have thrombus removal vs. those with usual care.